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Gulf War Illness Caused by Bacteria, Doctors
Say
Sunday, March 9, 1997
Disease: Some claim to have caught the ailment from veterans.
Others say theory lacks hard evidence. By J.R. MOEHRINGER, Times
Staff Writer
IRVINE--A number of medical professionals, who say they've become
ill while treating Gulf War veterans, claim the mysterious disease
afflicting tens of thousands of soldiers is contagious and could
pose a public health threat. Doctors, nurses, laboratory researchers,
as well as others who come in casual contact with Gulf War veterans,
say they've contracted the same symptoms --fatigue, fever, aches,
rashes and respiratory problems--that are generally associated
with "Gulf War syndrome." Government investigators as
well as some prominent scientists express deep skepticism about
such theories, and they find little evidence to support the claim
that Gulf War illnesses are contagious. But despite failing to
find favor with official Washington and colleagues, many remain
convinced that the cause of Gulf War illness is an infectious
microbe, either native to the Middle East or produced by Iraq's
infamous biological weapons program.
Whatever the cause, they say, it's spreading. As proof, they
cite themselves. "Everyone in this office has had Gulf War
illness," said Garth Nicolson, an Irvine biochemist at the
nonprofit Institute for Molecular Medicine, which he founded to
investigate Gulf War syndrome and other chronic conditions. "I
lost four teeth and had part of my lower jaw removed." The
inspiration for Nicolson's Irvine institute, which opened its
doors to Gulf War veterans in August, was his daughter-in-law,
a 101st Airborne Division soldier who became ill after her unit
penetrated deep into Iraq during the 1991 conflict. "Practically
everyone in her unit came down with Gulf War illness," said
Nicolson, who at that time was heading the tumor biology department
at the renowned M.D. Anderson Cancer Center in Houston.
"We found out a lot of people in the service were becoming
sick, and we'd seen similar illnesses before." After intense
clinical research and thorough examinations of his daughter-in-law,
Nicolson and his biophysicist wife, Nancy, concluded that Gulf
War illness could be treated with massive doses of antibiotics.
"She's fully recovered," he said of his daughter-in-law.
"She's going to be entering medical school." Until recently,
many suspected that Gulf War illnesses were caused by chemical
weapons. Nicolson and others, however, say chemical weaponry has
been a red herring. He argues that the leading culprit may be
a bacterium, such as mycoplasma fermentans, which he claims to
have found in the blood of 45% of the ailing veterans he's tested.
Perhaps genetically altered by the Iraqis or their weapons suppliers,
mycoplasma fermentans might have been a biological warfare agent
used in warheads that exploded above allied troop positions during
the Persian Gulf conflict, Nicolson contends. Or it may have been
dispersed in some other way by the Iraqis. Such theories have
circulated among investigators for some time, but have failed
to win many converts in Washington. "We saw [mycoplasma fermentans]
as a highly unlikely candidate for biological warfare," said
Dr. Shyh-Ching Lo, chief of the Division of Molecular Pathology
at the Armed Forces Institute of Pathology in Washington. He recently
studied Nicolson's data and found it inconclusive. "If 50%
of veterans were infected, we anticipate they would have a much
higher incidence of antibody response, but we did not really see
that," Lo said.
In its final report two months ago, the Presidential Advisory
Committee on Gulf War Veterans' Illnesses also discounted Nicolson's
arguments about the likely source of Gulf War syndrome. "Clinical
evidence seems to indicate that mycoplasma is not a source of
widespread illness in Gulf War veterans," said Mark Brown,
a senior policy analyst on the committee, which will continue
to oversee Pentagon investigations into Gulf War illnesses. "What
clinical evidence?" Nicolson asked. "They've never presented
any clinical evidence that mycoplasma wasn't involved, because
all signs and symptoms of Gulf War illness can be caused by mycoplasmal
infections." Despite the committee's findings, doctors at
Walter Reed Army Medical Center near Washington recently agreed
to work with Nicolson. "A protocol for evaluating Dr. Nicolson's
work is being developed now," said Walter Reed spokesman
Ben Smith. "Everybody involved with Gulf War illness, all
the folks here at Walter Reed and elsewhere, have said we'll look
at anything that'll help patients."
The Senate Veterans Affairs Committee, after hearing testimony
from many worried veterans, has vowed to investigate the contagion
question. "We've had lot of veterans testify that they are
concerned they are passing on these illnesses to their wives and
children," said Charles Battaglia, the committee's staff
director. "It's one of the things we'll be looking at as
part of the investigation this committee is conducting."
Joyce Riley, a former Air Force flight nurse in Houston, testified
before the committee that she became ill while treating soldiers
who returned from the Gulf War. Though she never left the United
States during her tour of duty, she quickly began to show symptoms
identical to those of her patients, including the debilitating
chronic fatigue that now afflicts many veterans. At one point,
Riley said, she was too weak to brush her teeth. When Riley recovered--thanks,
she says, to intravenous antibiotics similar to those used on
Nicolson's daughter--she founded the American Gulf War Veterans
Assn., a Texas-based organization that answers veterans' questions
and collects data on their health. She was lucky, she says, because
she received prompt medical attention.
Thousands of veterans have died, she believes, because their
conditions went unrecognized and misdiagnosed. Among the veterans
who have contacted her organization, Riley says, 80% report that
they've transmitted their illness to at least one other person,
including children, neighbors and co-workers. Many veterans even
describe bizarre symptoms in their household pets. "Here's
the scary part," she said. "When I talk to veterans,
I ask, 'How're the children doing?' And they say, 'Well, my little
boy cries at night because his muscle aches are so bad.' And I
say, 'Tell me about your pets.' And they tell me, 'Well, our pets
died.' " Frequently, Riley hears from physicians who are
sick. And scared. "A doctor called me the other day, and
he's been treating Gulf War veterans," she said. "Both
his prize dogs are dragging their back legs, and he's sick too."
Dr. Kathy Leisure, of Lebanon, Pa., has no doubt that the illness
is an infectious disease. She has treated 600 Gulf War veterans,
and one day noted a Gulf War-type rash on her nose. "Even
now people are getting the illness," she said. Said Nicolson:
"Saddam Hussein threatened to carry the war Return to America.
This is one way he could do that."
One of Nicolson's supporters is Dr. Edward S. Hyman, a New Orleans
physician who has treated nearly a dozen Gulf War veterans without
becoming ill himself--though he checks himself regularly for unusual
bacteria he believes responsible for Gulf War illness. Hyman,
who has testified before Congress about Gulf War illness, has
warned that the nation's blood supply, much of which is donated
by active duty military personnel, may be unsafe. "It's conceivable,"
said Hyman, who added that Gulf War illness behaves like the bacterial
infections he has studied for 30 years. "I'm not the kind
of guy who screams 'germ warfare' when there's no evidence for
it. Though I have better evidence than most anybody." Dr.
Charles Hinshaw, of Wichita, Kansas., agrees. A former president
of the American Academy of Environmental Medicine, he hasn't become
sick treating Gulf War veterans, but he believes that many of
their illnesses are contagious. He handles their blood with great
care. "If I was running the Red Cross," he said, "or
I was part of the Department of Defense, I'd say, 'Let's don't
take any more blood from veterans until we answer this question.'
"
Officials at the American Red Cross, which collects 50% of the
nation's blood supply, dismiss such concerns. "We make sure
before we collect blood from anybody that they feel well, that
they're in good health, and have normal temperature and pulse,"
said Dr. Peter L. Page, senior medical officer for biomedical
services at the American Red Cross. "Those practices have
protected transfusions very well over the decades from bacterial
contamination." But Nicolson and others charge that because
mycoplasma fermentans and some other bacteria have long incubation
periods, carriers may not always display outward symptoms of illness.
More than five years after the war's end, "we're just now
beginning to see secondhand exposures in physicians and nurses,"
said Nicolson, adding: "This is not going to go away, just
slowly spread." It spread like wildfire through his office.
Besides himself and his wife, five staffers came down with classic
symptoms of Gulf War illness." There's 123 different possible
symptoms," said Blake Hale, 22, a member of Nicolson's staff,
which includes physicians and chemists. "I've experienced
probably three-quarters of those."
Some of Hale's friends had trouble believing that his recent
sickness was in any way connected to the Gulf War, since he's
never spent a day in the military. But such skeptics have an even
harder time believing the recovery he's made. Along with everyone
else in Nicolson's office, he feels just fine after receiving
treatment with antibiotics. The drugs don't cure the disease,
doctors say, but they do control the symptoms. Among Nicolson's
most dramatic treatment successes is Dr. Larry Goss, of Walters,
Okla. When Goss and his wife began suffering from severe chronic
fatigue several years ago, they couldn't imagine the cause. Gulf
War syndrome never occurred to them since neither had served in
the military. As his wife's condition deteriorated into something
resembling multiple sclerosis--a common diagnosis, Goss said,
among Gulf War veterans who are sick--Goss heard about Nicolson's
research. It was only then that Goss began to wonder if his volunteer
work with local Gulf War veterans had caused his illness and that
of his wife. At Nicolson's suggestion, the Gosses took massive
doses of an antibiotic called doxycycline. Almost instantly, both
felt better. "She threw away her cane," Goss said, "and
no longer needed her wheelchair." Since his dramatic recovery,
and especially his wife's, Goss has become a firm believer in
Nicolson's theories.
For little or no money, he examines hundreds of Gulf War veterans,
many of whom come long distances, all of whom seem terribly frightened.
"I'm just a country doctor who got sick and saw a lot of
my patients sick and didn't know what was going on," he said.
"I'm no expert. I don't think anyone is. We need to learn
more." Said Riley: "It's startling. We're sitting on
top of a contagious disease and doing nothing about it."
Copyright © Los Angeles Times
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